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KMID : 0384320000210050635
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Korean Journal of Family Medicine
2000 Volume.21 No. 5 p.635 ~ p.644
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Related factors of peptic ulcer in H. pylori positive patients confirmed by endoscopic biopsy of stomach
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Oh Soon-Young
Lee Sok-Goo
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Abstract
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Background : This study was conducted to investigate the reason why H. pylori infected people develop different patterns of gastric disease and in some infected patients have peptic ulcers, but the others have not.
Methods : We analyzed 177 cases of H. pylori positive patients who were confirmed by histologic evaluation of gastric endoscopic biopsy specimens from January 1998 to July 1998 in Health Promotion Center of one medical college ospital. Among these 177 cases, 63 cases(35.6%) were peptic ulcer patients and 114 cases(64.6%) were non ulcer patients. We analyzed the difference of sociodemographic findings, alcohol and smoking habit, past history, family history, drug istory, emotional factors, body mass index and serum biochemical profiles between ulcer and non ulcer patients.
Results : 1. There were no differences of age, sex, and occupation between peptic ulcer and non ulcer patients. 2. Heavy smoking (p〈0.001), heavy drink (p=0.011), past history of upper gastrointestinal disease (p〈0.001), fatigue (p〈0.001) and depressive mood (p=0.001) were significantly more frequent in H. pylori positive peptic ulcer patients than non ulcer patients. 3. We found several related factors that might affect peptic ulcer development in H. pylori infected patients through logistic regression analysis of variables. There factors were heavy smoking (odds ratio 5.91, 95% CI 2.54-13.78), past history (odds ratio=4.24, 95% CI 1.72-10.42), depressed mood (odds ratio 2.76, 95% CI 1.15-6.63), and fatigue (odds ratio 2.42, 95% CI 1.03-5.69).
Conclusion : We conclude that history, heavy smoking, depressed mood, and fatigue are related factors of peptic ulcer disease in H. pylori positive patients.
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KEYWORD
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H. pylori, risk factors, peptic ulcer, gastricfiberscope, biopsy
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